Round 2 details (I wont' know anything until May12th at the earliest)

April 16th call the doc and make the Ultrasound appointment, get more letrozole, start all over again.  The one good thing about not getting pregnant is that you immediately go into the next cycle.  Miscarriages on the other hand set you back months.  Both are most likely due to chromosomal abnormalities in my case since I know I ovulated, I know I got enough sperm at the right time and that the sperm were active healthy and happy and all of that.  I also happen to know from my earlier Hysterosalpingogram (x-ray with radioactive dye injected into the uterus) that my fallopian tubes are clear of obstruction so sperm can get through there to the egg and the egg will be able to get through to the uterus after fertilization.  So it is very unlikely that fertilization did not take place, but very likely that something is wrong and the cells can't divide properly or the blastocyst can't implant.  Implantation was one of my earlier concerns as my uterus had some major complications that were alleviated with surgery.  The last ultrasound from round 1 shows my uterus to be free of fibroids and a very healthy thickness of the functional layer of endometrium too, so it is really up to the damn chromosomes....

There is a lot of research on aneuploidy in meiosis and a ridiculous amount of data showing that I waited longer than I should have to start trying, but there is also some data out there on other genetic defects that can lead to failure before implantation (blastocyst stage).  Here is an interesting image from a 2004 article in the Journal Reproduction:

http://www.reproduction-online.org/content/128/3/281.full.pdf+html

All of this fascinates me and so researching keeps my interest rather than focusing on being sad or thinking about why it didn't work.

So I'll take letrozole again 4/18-4/22, gonna try it in the morning this time.   And then I have my ultrasound to see how the follicles are doing on 4/26.  Nothing to really report until then and even then not much to say, but  keeping my fingers crossed or I'll have to buy more sperm!